Nonsteroidal Antiinflammatory Agents. 1. 10,11-Dihydro-11-oxodibenzoxepinacetic Acids and Related Compounds

DOI: 10.1021/jm00351a012

Source and publish data:

Journal of Medicinal Chemistry p. 1065 - 1070 (1982)

Update date:2022-08-04

Topics:

Authors:

Nagai, Yasutaka

Irie, Akira

Nakamura, Hideo

Hino, Katsuhiko

Uno, Hitoshi

Nishimura, Haruki

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Article abstract of DOI:10.1021/jm00351a012

10,11-Dihydro-11-oxodibenzoxepinacetic acids and related compounds were synthesized as potential antiinflammatory agents.Among them, 2-(8-methyl-10,11-dihydro-11-oxodibenzoxepin-2-yl)propionic acid (16b) and its thiepin analogue (16c) showed excellent antipyretic activity together with potent antiinflammatory and analgesic properties in biological tests.Structure-activity relationships are discussed.

Full text of DOI:10.1021/jm00351a012

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