Nonsteroidal Antiinflammatory Agents. 1. 10,11-Dihydro-11-oxodibenzoxepinacetic Acids and Related Compounds

Article abstract of DOI:10.1021/jm00351a012

10,11-Dihydro-11-oxodibenzoxepinacetic acids and related compounds were synthesized as potential antiinflammatory agents.Among them, 2-(8-methyl-10,11-dihydro-11-oxodibenzoxepin-2-yl)propionic acid (16b) and its thiepin analogue (16c) showed excellent antipyretic activity together with potent antiinflammatory and analgesic properties in biological tests.Structure-activity relationships are discussed.