Chemistry of Heterocyclic Compounds p. 1286 - 1288 (1992)
Update date:2022-09-26
Topics:
Demina, L. M.
Gavrilov, M. Yu.
Shurov, S. N.
Konshin, M. E.
The amides of 2-arylamino-4,6-dimethyl-2-chloronicotinic acid have been prepared. It has been shown that on account of steric hindrance on the part of the methyl group on the C(4) atom the conjugation of the amide function with the pyridine ring is broken and its influence on the mobility of the halogen is weakened, and the compound enters into a given reaction with more difficulty than its 6-monomethyl homolog.
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