SYNTHESIS OF AMIDES OF 2-ARYLAMINO-4,6-DIMETHYLNICOTINIC ACID

Article abstract of DOI:10.1007/BF00532079

The amides of 2-arylamino-4,6-dimethyl-2-chloronicotinic acid have been prepared. It has been shown that on account of steric hindrance on the part of the methyl group on the C₍₄₎ atom the conjugation of the amide function with the pyridine ring is broken and its influence on the mobility of the halogen is weakened, and the compound enters into a given reaction with more difficulty than its 6-monomethyl homolog.