Chemistry of Heterocyclic Compounds p. 511 - 514 (1982)
Update date:2022-08-04
Topics:
Shramm, N. I.
Konshin, M. E.
A substituted nicotinic acid is formed when 6-methyl-2-anilinonicotinonitrile is refluxed with concentrated hydrochloric acid, whereas 4,6-dimethyl-2-anilinonicotinonitrile is not hydrolyzed under these and more severe conditions because of steric hindrance.Both of these nitriles undergo cyclization to 10-aminobenzo-1,8-naphthyridine derivatives under the influence of concentrated sulfuric acid.When 6-methyl-2-arylaminonicotinonitriles are heated in polyphosphoric acid (PPA), they are converted to 2-arylaminonicotinic acid amides and, in part, to benzo-1,8-naphthyrid-10-one derivatives, while 4,6-dimethyl-2-arylaminonicotinonitriles are converted primarily to 10-aminobenzo-1,8-naphthyridines.
View Morewebsite:http://www.p-oled.cn/
Contact:+86-29-81101199
Address:No. 1199, Dingkunchi 3rd Road, High Tech Zone, Xi'an, Shaanxi, China,710119
Triumph International Development Limilted
website:http://www.jiashengchem.cn/
Contact:+86-536-7971999
Address:Yinhai Road,Shouguang
Improve Medical Technology(Nanxiong) Co., Ltd
Contact:86-751-3836997
Address:No.33, Pingan First Road, Fine Chemical Industry Base, Nanxiong City, Shaoguan, Guangdong, China
HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.
Contact:+86-186-02659358
Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China
Taizhou Huading Chemical Co.,Ltd(expird)
Contact:+86-576-88583898
Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Doi:10.1016/j.bmcl.2005.07.074
(2005)Doi:10.1016/j.tet.2004.10.030
(2004)Doi:10.1016/S0040-4039(00)87321-9
(1982)Doi:10.1039/d0sc01349h
(2020)Doi:10.1246/cl.1982.891
(1982)Doi:10.1246/cl.1982.875
(1982)
