Journal of Medicinal Chemistry p. 1358 - 1363 (1982)
Update date:2022-08-05
Topics:
Kanao, Munefumi
Hashizume, Takeshi
Ichikawa, Yoshifumi
Irie, Kiyoshi
Isoda, Sumiro
N-<(Benzoyloxy)alkyl>-1,2,3,4-tetrahydro-2-naphthylamine derivatives were synthesized from 1,2,3,4-tetrahydro-2-naphthylamines evaluated for their spasmolytic activity.Some of these compounds showed a nerve-selective effect on colon rather than stomach in anesthetized dogs and were found to be equal to or more active than the reference drug (mebeverine).The biological data have indicated some structure-activity relationships.Among these compounds, N-ethyl-N-<6-<(3,4-dimethoxybenzoyl)oxy>hexyl>-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine hydrochloride (63) was found to be the most active spasmolytic agent.
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Doi:10.1016/S0040-4039(00)86752-0
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