Journal of Medicinal Chemistry p. 1402 - 1407 (1982)
Update date:2022-07-29
Topics: Esters (Aryloxy)propanolamines
Erhardt
Woo
Gorczynski
Anderson
In an attempt to produce short-acting β-adrenergic receptor blocking agents, we prepared several (aryloxy)propanolamines with ester functions incorporated into the nitrogen substituent. Many of these compounds exhibited a short duration of blocking activity after their continuous intravenous infusion for 40 min. However, their durations were found to increase considerably upon longer intravenous infusion.
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Doi:10.1107/S0567740882009054
(1982)Doi:10.1055/s-1982-29844
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