Journal of Organic Chemistry p. 4963 - 4968 (1982)
Update date:2022-08-04
Topics:
Cooke, Manning P.
Charge-directed conjugate addition reactions have been applied to the preparation of highly substituted ketones.Acylphosphoranes resulting from conjugate addition-alkylation reactions are reduced by Al-Hg to β-keto esters, which, upon alkylation and hydrolysis, give ketones in high yields.An application of this methodology to the synthesis of 9, the defense substance of L. longipes, is described.
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