CONVERGENT SOLID PHASE PEPTIDE SYNTHESIS. I. SYNTHESIS OF PROTECTED SEGMENTS ON A HYDROXYMETHYLPHENYLOXYMETHYL RESIN USING THE BASE LABILE FMOC α-AMINE PROTECTION. MODEL SYNTHESIS OF LHRH.

Article abstract of DOI:10.1016/0040-4020(82)85102-8

Convergent solid phase peptide synthesis has been applied to yield LHRH.The segments 1-6 and 7-10 of LHRH were synthesized on a hydroxymethylphenoxymethyl resin using the base labile Fmoc protecting group on the α-amines.The side chains were protected by