Bulletin of the Chemical Society of Japan p. 425 - 432 (1998)
Update date:2022-09-26
Topics:
Dao, Duc Hai
Kawai, Yasushi
Hida, Kouichi
Bornes, Sander
Nakamura, Kaoru
Ohno, Atsuyoshi
Okamura, Mutsuo
Akasaka, Takeshi
Alkyl 2-oxo-4-phenylbutyrates are reduced to the corresponding alkyl (R)-2-hydroxy-4-phenylbutyrates, versatile chiral building blocks in organic synthesis, in high chemical yield (80-90%) with excellent stereoselectivity (>90%ee). The reaction has been run in aqueous diethyl ether at 30 °C for 24 h under the catalysis of bakers' yeast (Saccharomyces cerevisiae) which was preincubated for 6 h in the presence of phenacyl chloride. The amount of water in the medium should be controlled strictly not to exceed 0.8 mL (g yeast)-1.
View MoreShanghai ZaiQi Bio-Tech Co., Ltd.,
Contact:+86-21-5482 4098
Address:Bldg. No.7, No.201 MinYi Rd,Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
Contact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
Tianjin Dongchang Fine Chemical Industry Co., Ltd.
Contact:+86-22-29894595
Address:Economic Developing Zone, Ji County, Tianjin, China
Wuhan Kemi-Works Chemical Co., Ltd
website:http://www.kemiworks.com
Contact:86-27-85736489
Address:Rm. 1503, No. 164, Jianghan North Rd., Wuhan, 430022 China
Xuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
Doi:10.1002/hlca.200790180
(2007)Doi:10.1002/asia.201402323
(2014)Doi:10.1021/jm00355a017
(1983)Doi:10.1021/jo00148a027
(1982)Doi:10.1021/jm040873u
(2005)Doi:10.1039/c5ob02229k
(2016)