Journal of Medicinal Chemistry p. 222 - 226 (1983)
Update date:2022-07-30
Topics:
Hino
Nakamura
Nagai
Uno
Nishimura
A series of [(heteroarylamino)phenyl]alkanoic acids pyridine, quinoline, or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino)phenyl]propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects. Structure-activity relationships are discussed.
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