Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids

DOI: 10.1021/jm00356a019

Source and publish data:

Journal of Medicinal Chemistry p. 222 - 226 (1983)

Update date:2022-07-30

Topics:

Authors:

Hino Hino

Nakamura

Nagai Nagai

Uno Uno

Nishimura

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Article abstract of DOI:10.1021/jm00356a019

A series of [(heteroarylamino)phenyl]alkanoic acids pyridine, quinoline, or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino)phenyl]propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects. Structure-activity relationships are discussed.

Full text of DOI:10.1021/jm00356a019

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