Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids

DOI: 10.1021/jm00356a019

Source and publish data:

Journal of Medicinal Chemistry p. 222 - 226 (1983)

Update date:2022-07-30

Topics:

Authors:

Hino Hino

Nakamura

Nagai Nagai

Uno Uno

Nishimura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00356a019

A series of [(heteroarylamino)phenyl]alkanoic acids pyridine, quinoline, or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino)phenyl]propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects. Structure-activity relationships are discussed.

Full text of DOI:10.1021/jm00356a019

Products guided by the article

Product name:[3-(Pyridin-2-ylamino)-phenyl]-acetic acid methyl ester

Cas No:83528-28-3

R&D Labs maybe for 83528-28-3

Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
BioBioPha Co., Ltd

Contact:+86-871-65217109

Address:132 Lanhei Road, Kunming Institute of Botany, Chinese Academy of Sciences
Suzhou Shanyang New Material Co., Ltd

Contact:86-13862023007

Address:No.558 Foho Avenue of Wujiang District
Suzhou Chiral Pharmaceuticals Co., Ltd.

Contact:86-0512-63197058

Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
Shandong Bolode Bio-Technology Co., LTD

Contact:+86-0531-58966870

Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China

Relevant to this article

Synthesys and Characterization of Paramagnetic Triazenido-complexes of Rhenium(III). The Crystal Structure of

Doi:10.1039/DT9820001949
(1982)
Liquid crystal dimers having vary oxyethylene flexible spacers

Doi:10.1080/15421406.2016.1263102
(2017)
Efficient Access to 2,3-Dihydroquinazolin-4(1 H)-ones by Environmentally Benign l -Proline Nitrate as Recyclable Catalyst

Doi:10.1055/s-0035-1560483
(2015)
MICROBIAL TRANSFORMATION OF 17α-CYANOMETHYL-17-HYDROXY-4,9-ESTRADIEN-3-ONE (STS 557) AND 17α-CYANOMETHYL-19-NORTESTOSTERONE BY MYCOBACTERIUM SMEGMATIS

Doi:10.1016/0039-128X(82)90064-2
(1982)
Palladium-Catalyzed Regioselective C-H Functionalization/Annulation Reaction of Amides and Allylbenzenes for the Synthesis of Isoquinolinones and Pyridinones

Doi:10.1021/acs.joc.1c00150
(2021)
A concise benzotriazolyl-mediated synthesis of 9-methoxycepharanone A

Doi:10.1016/j.tet.2004.10.079
(2005)

Article Doi