ACYCLIC STEREOSELECTION. 15. SEQUENTIAL ALDOL-CLAISEN AS A METHOD FOR 1,5-STEREOSELECTION. TOTAL SYNTHESIS OF THE VITAMIN-E SIDE CHAIN

DOI: 10.1016/S0040-4039(00)88423-3

Source and publish data:

Tetrahedron Letters p. 2825 - 2828 (1982)

Update date:2022-08-05

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Authors:

Heathcock, Clayton H.

Jarvi, Esa T.

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Article abstract of DOI:10.1016/S0040-4039(00)88423-3

Alcohol 1, the side chain of α-tocopherol, has been synthesized in a stereoselective route involving an aldol condensation-Claisen rearrangement sequence.The synthesis requires 11 steps and produces 1 in 17percent overall yield.A complementary sequence em

Full text of DOI:10.1016/S0040-4039(00)88423-3

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