A NOVEL METHOD FOR THE SYNTHESIS OF α,β-DIHYDROXY KETONES via TIN(II) ENEDIOLATES

Article abstract of DOI:10.1246/cl.1982.1291

Activated metallic tin, prepared from stannous chloride and metallic potassium, reacts readily with α-dicarbonyl compounds to form tin(II) enediolates, which in turn react with aldehydes under a mild reaction condition to give α,β-dihydroxy ketones in good yields.The reaction proceeds stereoselectively in the presence of hexafluorobenzene.