Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives. 2. 7-Acyl Amide Analogues

DOI: 10.1021/jm00357a015

Source and publish data:

Journal of Medicinal Chemistry p. 403 - 411 (1983)

Update date:2022-08-05

Topics: Antihypertensive Activity

Authors:

Blankley, C. John

Bennett, Lawrence R.

Fleming, Robert W.

Smith, Ronald D.

Tessman, Deirdre K.

Kaplan, Harvey R.

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Article abstract of DOI:10.1021/jm00357a015

The effect of acylation with a variety of acids on the antihypertensive activity of 6-(2,6-dichlorophenyl)pyrido<2,3-d>pyrimidin-7-amine (1) is reported, and structure-activity relationships are discussed.Although several of the compounds show good oral a

Full text of DOI:10.1021/jm00357a015

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