Journal of Medicinal Chemistry p. 403 - 411 (1983)
Update date:2022-08-05
Topics: Antihypertensive Activity
Blankley, C. John
Bennett, Lawrence R.
Fleming, Robert W.
Smith, Ronald D.
Tessman, Deirdre K.
Kaplan, Harvey R.
The effect of acylation with a variety of acids on the antihypertensive activity of 6-(2,6-dichlorophenyl)pyrido<2,3-d>pyrimidin-7-amine (1) is reported, and structure-activity relationships are discussed.Although several of the compounds show good oral a
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