Journal of the Iranian Chemical Society p. 671 - 680 (2012)
Update date:2022-09-26
Topics:
Devi, C. Shobha
Nagababu, Penumaka
Shilpa
Kumar, Y. Praveen
Reddy, M. Rajender
Gabra, Nazar Md
Satyanarayana
A series of four polypyridyl Ru(II) complexes such as [Ru(L) 4(PIP)]2+ and [Ru(L)4PPIP]2+ where L is 4-amino pyridine and Pyridine (PIP = 2-phenylimidazo[4,5-f] [1, 10] phenanthroline), (PPIP = 2-(40-phenoxy-phenyl) imidazo[4,5-][1, 10]phenanthroline) have been synthesized and characterized by elemental analysis, physicochemical methods such as UV-vis, IR and NMR spectroscopic techniques. The DNA-binding behavior of these complexes was investigated by electronic absorption titrations, fluorescence spectroscopy, viscosity measurements and salt-dependent studies. The experimental results indicate that all these complexes can bind to DNA through an intercalation mode, the DNA-binding affinities of these complexes follow the order [Ru(4-APy) 4(PPIP)]2+(1)[[Ru(Py)4PPIP]2+(2) < [Ru(4-APy)4(PIP)]2+(3)[[Ru(Py)4PIP] 2+(4). Noticeably, these complexes have been found to be efficient photosensitisers for strand scissions in plasmid DNA. Further, all four complexes screened for their antimicrobial activity indicate that the complexes show appreciable activity against Escherichia coli and Neurospora Crassa. In addition, in the presence of Co2+, the emission of DNA-[Ru(L 4)PPIP/PIP]2+ can be quenched and recovered by the addition of EDTA, which exhibited the DNA "light switch" properties. Iranian Chemical Society 2012.
View MoreContact:+86-570-4336358
Address:No.87 Building,Tianqian,Sidu Town
Contact:+86-134-5286-9121
Address:Add: Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong,
Rugao Jinling Chemical Co., Ltd.(expird)
Contact:0086-513-68005586
Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
Hangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Suzhou Ryan Pharmachem Technology Co.,Ltd
Contact:+86-0512-68780025
Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
Doi:10.1007/BF00645940
(1963)Doi:10.1007/s10593-006-0204-1
(2006)Doi:10.1002/cssc.200900228
(2010)Doi:10.1016/j.tetlet.2007.03.152
(2007)Doi:10.1039/b618833h
(2007)Doi:10.1080/07328300701296810
(2007)