Journal of Organic Chemistry p. 10 - 14 (1987)
Update date:2022-08-02
Topics:
Piccolo, Oreste
Spreafico, Franca
Visentin, Giuseppina
Valoti, Ermanno
The preparation of (S)-2-(4'-isobutylphenyl)propionic acid ((S)-Ibuprofen) (82percent optical purity) and (S)-2-(6'-methoxy-2'-naphthyl)propionic acid (Naproxen) (96percent optical purity) has been accomplished by starting from optically pure (S)-2-chloropropionyl chloride.The investigation for finding the best experimental conditions and minimizing racemization phenomena is presented.
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