Catechol Estrogens of the 1,1,2-Triphenylbut-1-ene Type: Relationship between Structure, Estradiol Receptor Affinity, Estrogenic and Antiestrogenic Properties, and Mammary Tumor Inhibiting Activities

Article abstract of DOI:10.1021/jm00158a006

1,1,2-Triphenylbut-1-enes (26-35), which are substituted with one or two 3,4-diacetoxy groups or with one 3,4-diacetoxy and one 3- or 4-acetoxy group in two aromatic rings, were synthesized.The occurring E and Z isomers were isolated, and their identity w