α-METHYL AMINO ACIDS BY CATALYTIC PHASE-TRANSFER ALKYLATIONS

Article abstract of DOI:10.1016/S0040-4039(00)88719-5

The α-methyl amino acids, α-methyl p-chlorophenylalanine, α-methyl p-tyrosine, α-methyl m-tyrosine and α-methyl DOPA have been prepared in good yields from amino ester hydrochlorides.The key step in the method is the catalytic phase-transfer alkylation of Schiff base derivatives of monoalkyl amino acids.