
Journal of the Chemical Society. Perkin transactions I p. 413 - 418 (1994)
Update date:2022-07-30
Topics:
Moriya, Osamu
Takenaka, Hideo
Iyoda, Masaichi
Urata, Yoshikiyo
Endo, Takeshi
Nitrile oxides were generated readily by the reaction of aldoximes 1, with tert-butyl hypochlorite and bis(tributyltin) oxide.The reaction proceeded efficiently under mild conditions, in which O-stannylated aldoximes 2 are thought to be key intermediates.This reaction system was applicable to the one-pot syntheses of isoxazole derivatives 4 and 5 in the presence of dipolarophiles via a <3 + 2> cycloaddition.
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