Quantitative Structure-Inotropy Relationship Applied to Substituted Grayanotoxins

DOI: 10.1021/jm00360a012

Source and publish data:

Journal of Medicinal Chemistry p. 851 - 855 (1983)

Update date:2022-07-31

Topics:

Authors:

Shirai, Naohiro

Sakakibara, Jinsaku

Kaiya, Toyo

Kobayashi, Sawako

Hotta, Yoshihiro

Takeya, Kazumi

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Article abstract of DOI:10.1021/jm00360a012

Nine 14β-O-acylated grayanotoxins were synthesized by ozonolysis of 14,16-alkylidenegrayanotoxin III.The correlation between positive inotropic potency (PIE) in guinea pigs and physicochemical parameters (Vw, Mw, and Rm₅₀) in 14,14-substituted

Full text of DOI:10.1021/jm00360a012

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