Studies on the Chinese crude drug 'Forsythiae fructus.' VI. The structure and antibacterial activity of suspensaside isolated from Forsythia suspensa

DOI: 10.1248/cpb.30.4548

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 4548 - 4553 (1982)

Update date:2022-08-03

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Authors:

Nishibe Nishibe

Okabe Okabe

Tsukamoto

Sakushima

Hisada Hisada

Baba Baba

Akisada Akisada

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Article abstract of DOI:10.1248/cpb.30.4548

A new caffeoyl glycoside of β,3,4-trihydroxyphenethyl alcohol, designated as suspensaside (1), was isolatd from the fruits of Forsythia suspensa Vahl (Oleaceae). The structure of 1 was established as DL-β,3,4-trihydroxyphenethyl-O-α-L-rhamnopyranosyl-(1→6)-4-0-caffeoyl-b-D-glucopyranoside on the basis of analysis of the carbon-13 nuclear magnetic resonance spectrum and chemical evidence. Compound 1 exhibited antibacterial activity against Staphylococcus aureus Terashima, with MIC 4.1 mM (2.6 mg/ml).

Full text of DOI:10.1248/cpb.30.4548

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