DEALKYLATION OF NUCLEOSIDE ARYLMETHYL 2-CHLOROPHENYL PHOSPHATES: THE 2,4-DINITROBENZYL PROTECTING GROUP

DOI: 10.1016/S0040-4039(00)81574-9

Source and publish data:

Tetrahedron Letters p. 951 - 954 (1983)

Update date:2022-08-04

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Authors:

Christodoulou, Chris

Reese, Colin B.

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Article abstract of DOI:10.1016/S0040-4039(00)81574-9

Following a study of the effect of benzyl substitution on the rates of nucleophilic dealkylation of phosphotriesters, 2,4-dinitrobenzyl is proposed as a temporary protecting group for 3'-terminal phosphodiester functions in oligonucleotide synthesis.

Full text of DOI:10.1016/S0040-4039(00)81574-9

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