Preparation of optically active α-hydroxy oxime ether by diastereoselective imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of (+)-cytoxazone

Article abstract of DOI:10.1016/j.tetlet.2005.04.026

The diastereoselective imino 1,2-Wittig rearrangement of hydroximates provides a novel method for the construction of optically active α-hydroxy oxime ethers. Upon treatment with LDA, allyl p-methoxyphenylhydroximate carrying a chiral auxiliary smoothly u