The first synthesis of the ketene dithioacetals from sugar lactones: A convenient access to 3-ulosonic acids

Article abstract of DOI:10.1016/S0040-4039(98)01045-4

Isomeric 2-deoxy aldonolactones undergo Horner-Emmons reactions with 2- [bis(2,2,2-trifluoroethoxy)phosphoryl]1,3-dithiane, to give the corresponding ketene dithioacetals, which are the key intermediates in the synthesis of 3- deoxy-2-keto-aldonic acids.