Journal of Organic Chemistry p. 8339 - 8351 (2020)
Update date:2022-09-26
Topics:
Patel, Nitinchandra D.
Wei, Xudong
Byrne, Denis
Narayanan, Bikshandarkoil A.
Pennino, Scott
Sarvestani, Max
Saha, Anjan
Haddad, Nizar
Kapadia, Suresh
Lorenz, Jon C.
Decroos, Philomen
Ye, Andrew
Lee, Heewon
Grinberg, Nelu
Hossain, Azad
Busacca, Carl A.
Yee, Nathan K.
Senanayake, Chris H.
An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive SNAr reaction of 4-quinolinyl sulfones with a range of structurally diversified 1°, 2°, and 3° alcohols with a wide substrate scope and high yields. By adapting this methodology, a convergent synthesis of a complex target of HCV NS3/4a protease inhibitor BI 201420 was accomplished.
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