Tetrahedron Letters p. 4747 - 4750 (1982)
Update date:2022-08-03
Topics:
Heathcock, Clayton H.
Taschner, Michael J.
Rosen, Terry
Thomas, James A.
Hadley, Cheri R.
Popjak, George
Alcohols 14 and 21 and the derived half-glutarate esters 15 and 22 have been prepared and evaluated as inhibitors of HMG CoA reductase.Compound 14, the hexalin moiety of the natural fungal metabolite compactin (ML-236B) and compound 21, its isomeric diene, have essentially no inhibitory properties.Compound 15 and 22 show definite activity, although several orders of magnitude lower than that shown by compactin.
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