Lipophilic Lithium Carriers

Article abstract of DOI:10.1021/ja00350a012

The design, preparation, and properties of a new series of lipophilic lithium ion carriers are described.The structure of these carriers is based on an acyclic system in which a hexafunctional lipophilic envelope is formed around the metal ion in an octahedral arrangement.The synthesis involves a series of condensation rections using a cyclic tin-oxygen compound as an activated diol precursor.The carrier properties for lithium ions were demonstrated by in vitro experiments on liposomes using a fluorescence assay.The potential pharmacological applications of these ionophores are discussed.