Ring-Substituted 1,2-Dialkylated 1,2-Bis(hydroxyphenyl)ethanes. 1. Synthesis and Estrogen Receptor Binding Affinity of 2,2'-and 3,3'-Disubstituted Hexestrols

Article abstract of DOI:10.1021/jm00362a010

The syntheses of symmetrically 3,3'- and 2,2'-disubstituted meso hexestrol derivatives are described <3,3'-substituents: OH (1), F (2), Cl (3), Br (4), I (5), CH2N(CH3)2 (6), CH3 (7), CH2OCH3 (8), CH2OC2H5 (9), CH2OH (10), NO2 (11), NH2 (12) N(CH3)2 (13),