Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors

DOI: 10.1016/j.bmcl.2005.03.095

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2857 - 2860 (2005)

Update date:2022-09-26

Topics:

Authors:

Kwang, Seob Lee

Seon, Hee Seo

Yong, Ha Lee

Ha, Dong Kim

Moon, Ho Son

Bong, Young Chung

Jae, Yeol Lee

Jin, Changbae

Yong, Sup Lee

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Article abstract of DOI:10.1016/j.bmcl.2005.03.095

Excessive calpain activations contribute to serious cellular damage and have been found in many pathological conditions. Novel chromone carboxamides derived from ketoamides were prepared and evaluated for μ-calpain inhibition. Among synthesized, compound

Full text of DOI:10.1016/j.bmcl.2005.03.095

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