Potential antitumor agents. 42. Structure-activity relationships for acridine-substituted dimethyl phosphoramidate derivatives of 9-anilinoacridine

DOI: 10.1021/jm00374a020

Source and publish data:

Journal of Medicinal Chemistry p. 1053 - 1056 (1984)

Update date:2022-09-26

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Authors:

Rewcastle

Atwell Atwell

Baguley Baguley

Denny Denny

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Article abstract of DOI:10.1021/jm00374a020

Replacement of the 1'-methanesulfonamide group of the 9-anilinoacridine class of antitumor agents with the 1'-(dimethyl phosphoramidate) group provides compounds that are generally more lipophilic and bind more tightly to DNA. On the average, the dimethyl

Full text of DOI:10.1021/jm00374a020

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