Coupling Reaction of Acid Chlorides with Terminal Alkynes Catalyzed
Letters in Organic Chemistry, 2011, Vol. 8, No. 5
367
cyclohydrocarbonylation of ꢀ-keto alkynes catalyzed by
a
mmol), and DIEA (1.0 mmol). The mixture was stirred at
room temperature for 2 h under aerobic conditions. Upon
completion of the reaction, the reaction mixture was
dissolved in chloroform (5 ml). The palladium catalyst was
separated from the mixture by filtration, washed with water
(10 ml) and acetonitrile (10 ml), and reused in the next run.
The chloroform solution was then washed with water (5 ml)
and dried over MgSO4, and toluene (1.0 mmol) was added as
internal standard for GC analysis. After GC analysis, the
solvent was removed under vacuum, and the crude product
was subjected to silica gel column chromatography using
CHCl3–CH3OH (97:5) as eluent to afford the pure product.
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ACKNOWLEDGEMENT
Bakherad, M.; Keivanloo, A.; Bahramian, B.; Rajaie, M. A copper-
and solvent-free coupling of acid chlorides with terminal alkynes
catalyzed by a polystyrene-supported palladium(0) complex under
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The authors are grateful to the Research Council of
Shahrood University of Technology for financial support of
this work.
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