Preliminary studies of new proteasome inhibitors in the tumor targeting approach: Synthesis and in vitro cytotoxicity

Article abstract of DOI:10.1021/jm050181l

The proteasome is a multicatalytic protease that plays a critical role in the cell. The control of proteasomes could, thus, provide a weapon for the treatment of cancer. Therefore, we have synthesized six new peptide aldehyde inhibitors of the proteasome