Tetrahedron p. 1593 - 1596 (1983)
Update date:2022-08-03
Topics:
Faust, J.
Preiss, A.
Schreiber, K.
Ripperger, H.
The synthesis of (2S:3'S:3"S)-N-<3-(3-amino-3-carboxypropylamino)-3-carboxypropyl>-proline (1), a nicotianamine analogue with a 5-membered ring, was achieved by stepwise combination of S-proline ethyl ester (3) and (3S)-3-ethoxycarbonyl-3-trifluoroacetylaminopropionaldehyde (4) via reductive coupling.Compound 1 exhibits a smaller biological effect than nicotianamine (2) on phenotypical normalization of the tomato mutant chloronerva.
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Doi:10.1016/S0040-4039(01)01153-4
(2001)Doi:10.1002/anie.200501794
(2005)Doi:10.1016/j.poly.2005.03.047
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(1983)
