A Modified Benzhydrylamine as a Handle Reagent for the Solid Phase Synthesis of Peptide Amides Based on the Fluorenylmethoxycarbonyl Method

DOI: 10.1039/c39880000382

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 382 - 384 (1988)

Update date:2022-07-29

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Authors:

Funakoshi, Susumu

Murayama, Eigoro

Guo, Lili

Fujii, Nobutaka

Yajima, Haruaki

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Article abstract of DOI:10.1039/c39880000382

An easily preparable dimethoxybenzhydrylamine derivative, 3-(α-Fmoc-amino-4-methoxybenzyl)-4-methoxyphenyl propionic acid (Fmoc=fluoren-9-ylmethoxycarbonyl) is a useful precursor of the C-terminal amide, when applied to Fmoc-based solid phase peptide synthesis; as a cleavage reagent from the resine, thioanisole-mediated trimethylsilyl bromide in trifluoroacetic acid is recommended.

Full text of DOI:10.1039/c39880000382

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