Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis

DOI: 10.1016/j.bmcl.2005.08.057

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5160 - 5164 (2005)

Update date:2022-09-26

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Authors:

Revesz, Laszlo

Bollbuck, Birgit

Buhl, Thomas

Eder, Joerg

Esser, Ronald

Feifel, Roland

Heng, Richard

Hiestand, Peter

Jachez-Demange, Benedicte

Loetscher, Pius

Sparrer, Helmut

Schlapbach, Achim

Waelchli, Rudolf

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Article abstract of DOI:10.1016/j.bmcl.2005.08.057

Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.

Full text of DOI:10.1016/j.bmcl.2005.08.057

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