Journal of Pharmaceutical Sciences p. 700 - 702 (1983)
Update date:2022-08-05
Topics:
Brine
Boldt
Six derivatives of 3,3-diphenyl-2-pyrrolidone were synthesized and screened for anticonvulsant activity. The synthetic route involved a mono-N-demethylation of an intermediate N,N-dimethylaminonitrile with methyl chloroformate followed by cleavage of the carbamate group. Of the six derivatives, (±)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine hydrochloride was effective in protecting mice against maximal electroshock (MES)-induced seizures at a 30-mg/kg dose level.
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Doi:10.1021/jo051652e
(2005)Doi:10.1002/jhet.5570200331
(1983)Doi:10.1016/S0040-4020(01)91950-7
(1983)Doi:10.1021/ja00360a037
(1983)Doi:10.1021/jo052061r
(2006)Doi:10.1021/om0507272
(2006)
