Aldol Addition Reaction of Chiral Acetylurea and a Convenient Synthesis of Optically Pure Methyl β-Alkyl-β-hydroxypropionate

DOI: 10.1246/cl.1999.787

Source and publish data:

Chemistry Letters p. 787 - 790 (1989)

Update date:2022-08-04

Topics:

Authors:

Kishikawa, Keiki

Yamamoto, Makoto

Kohmoto, Shigeo

Yamada, Kazutoshi

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Article abstract of DOI:10.1246/cl.1999.787

The aldol addition reaction of chiral acetylurea with aldehydes diastereoselectively gives β-alkyl-β-hydroxypropionylureas (3 and 4) and the methanolysis of the adducts 3 and 4, separated perfectly by conventional column chromatography on silica gel, give

Full text of DOI:10.1246/cl.1999.787

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