Journal of Organic Chemistry p. 4658 - 4661 (1983)
Update date:2022-08-04
Topics:
Castaldi, Graziano
Belli, Aldo
Uggeri, Fulvio
Giordano, Claudio
A new method for the synthesis of α-arylalkanoic acids is given, based on Lewis acid promoted rearrangement of acetals of primary and secondary α-haloalkyl aryl ketones (halo = Br, Cl) in hydrocarbon solvents.The reaction is selective, providing the esters of α-arylalkanoic acids in almost quantitative yields.The ability of "soft and borderline" Lewis acids in activating the carbon-halogen bond is compared with that of silver salts.The reaction mechanism is discussed.The present synthesis has been applied to some α-arylpropionic acids well-known as antiinflammatory drugs.
View Morewebsite:http://www.mingchem.com/en/index
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Winchem Industrial Co. Ltd.(expird)
Contact:86-574-83851061 86-574-87083208
Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Changsha Nutritopper Bio Technology Co.,Ltd.
Contact:+86-731-87803543
Address:East 1st Street, Baima Road, Ningxiang County
Contact:86-571-87758773
Address:Room604 ,6F, Block A1-3 Xixi Plaza,No. 588 Wenyi West RD, Hangzhou,310012, China
Shanghai Standard Biotech Co., Ltd.
Contact:+86-18502101150
Address:Room 103, Building 2nd, NO.720, Cailun Road , Pudong District, Shanghai, China
Doi:10.1016/S0040-4039(98)01176-9
(1998)Doi:10.1021/jm401387j
(2013)Doi:10.1021/jo01140a008
(1952)Doi:10.1248/cpb.53.1502
(2005)Doi:10.1016/j.jorganchem.2014.12.023
(2015)Doi:10.1002/jlac.198319830804
(1983)
