Structure-Activity Relationship Study of the Inhibition of Adrenal Cortical 11β-Hydroxylase by New Metyrapone Analogues

DOI: 10.1021/jm00367a004

Source and publish data:

Journal of Medicinal Chemistry p. 15 - 19 (1984)

Update date:2022-08-04

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Authors:

Hays, Sheryl J.

Tobes, Michael C.

Gildersleeve, David L.

Wieland, Donald M.

Beierwaltes, William H.

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Article abstract of DOI:10.1021/jm00367a004

Metyrapone, 2-methyl-1,2-di-3-pyridil-1-propanone (1a), is a potent reversible inhibitor of the cytochrome P-450 11β-hydroxylase enzyme system (P-450_11β) of the adrenal cortex.The structural features of the metyrapone molecule have been systema

Full text of DOI:10.1021/jm00367a004

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