Structure-Activity Relationship Study of the Inhibition of Adrenal Cortical 11β-Hydroxylase by New Metyrapone Analogues

DOI: 10.1021/jm00367a004

Source and publish data:

Journal of Medicinal Chemistry p. 15 - 19 (1984)

Update date:2022-08-04

Topics:

Authors:

Hays, Sheryl J.

Tobes, Michael C.

Gildersleeve, David L.

Wieland, Donald M.

Beierwaltes, William H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00367a004

Metyrapone, 2-methyl-1,2-di-3-pyridil-1-propanone (1a), is a potent reversible inhibitor of the cytochrome P-450 11β-hydroxylase enzyme system (P-450_11β) of the adrenal cortex.The structural features of the metyrapone molecule have been systema

Full text of DOI:10.1021/jm00367a004

Products guided by the article

Product name:Pyridine, 3-(2-chloro-1,1-dimethyl-2-phenylethyl)-

Cas No:87372-77-8

R&D Labs maybe for 87372-77-8

Pengchen New Material Technology Co., Ltd.

Contact:+86-512-63680537

Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Beyond Pharmaceutical Co., Ltd

Contact:+86-571-8195-3185

Address:No. 13-1, Liansheng Road, Yuhang District
Sichuan Mianzhu Ronghong Chemical Co.,LTd

Contact:8613981840544

Address:XINSHI INDUSTRY PARK,MIANZHU,SICHUAN,CHINA
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Suns Chemical Sdn Bhd

Contact:0086 371 65711996

Address:Jalan 4/3, Kawasan Perindustrian Serendah, 48000 Rawang,

Relevant to this article

In search of simplicity and flexibility: A rational access to twelve fluoroindolecarboxylic acids

Doi:10.1002/ejoc.200600118
(2006)
Synthesis and stability of 3-hydroxyanagrelide, a biologically potent metabolite of anagrelide

Doi:10.3987/COM-12-S(N)115
(2012)
Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: Modifications of the oxazolidinone ring leading to the discovery of anacetrapib

Doi:10.1021/jm200484c
(2011)
Silylation-desilylation of propargyl amides: rapid synthesis of functionalised aldehydes and β-lactams

Doi:10.1016/j.tet.2007.04.064
(2007)
Hetero-Diels-Alder Reactions of 2-Methylene-1,3-dicarbonyl Compounds with Alkyl Vinyl Ethers

Doi:10.1039/c39830000281
(1983)
Synthesis of the C14-C28 fragment of tetronasin

Doi:10.1055/s-2005-918486
(2005)

Article Doi