Bioorganic and Medicinal Chemistry Letters p. 320 - 323 (2006)
Update date:2022-08-03
Topics: Cytotoxic Hybrid Experimental Synthetic Polyketides Leptomycin B Callystatin A
Marshall, James A.
Mikowski, Ann M.
Bourbeau, Matthew P.
Schaaf, Gregory M.
Valeriote, Frederick
Four stereoisomeric hybrids of the polyketide natural products callystatin A and leptomycin B have been prepared by parallel synthetic routes involving chiral allenylstannane methodology. Like their natural counterparts, these hybrids exhibit nanomolar le
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