Chemical and Pharmaceutical Bulletin p. 1469 - 1473 (1983)
Update date:2022-08-02
Topics:
Noji
Motoama
Tashiro
Kidani
Halogeno, sulfato, and nitrato Pt(II) complexes of 2,3-diaminopropranolol (pnOH) isomers were synthesized and their activities against leukemia L1210 were tested. The conformations of their chelate rings were determined to be λ- and δ-gauche forms for R- and S-pnOH, respectively, by 13C-nuclear magnetic resonance and circular dichroism spectral analyses. Among the pnOH isomers, Pt(II) complexes containing R-pnOH showed higher antitumor activity than those containing S- or racemic pnOH. It seems that there may be a relationship between the conformations of the chelate rings and antitumor activity in the case of five-membered chelate rings.
View MoreJinan Yijialian Economic and Trade Development Co., Ltd.
Contact:+86 0531-66729596
Address:jinan
website:http://www.mingchem.com/en/index
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Zhejiang Quzhou Zhengbang Organosilicon Co.,ltd.
Contact:86-570-3375195
Address:No.17 Lingqing Road technology industry,Quzhou City,Zhejiang Province,China
Beijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Contact:+(852) 301-98033
Address:Flat C, 23/F, Lucky Plaza, 315-321 Lockhart Road, Wan Chai, Hong Kong
Doi:10.1021/acs.jnatprod.6b00367
(2016)Doi:10.1248/cpb.31.1646
(1983)Doi:10.1055/s-2003-37122
(2003)Doi:10.1021/om050882g
(2006)Doi:10.1016/S0022-328X(00)89433-4
(1977)Doi:10.1039/P19830002011
(1983)
