Synthesis and antitumor activity of Pt(II) complexes containing 2,3-diaminopropanol isomers

DOI: 10.1248/cpb.31.1469

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Chemical and Pharmaceutical Bulletin p. 1469 - 1473 (1983)

Update date:2022-08-02

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Authors:

Noji Noji

Motoama Motoama

Tashiro Tashiro

Kidani Kidani

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Article abstract of DOI:10.1248/cpb.31.1469

Halogeno, sulfato, and nitrato Pt(II) complexes of 2,3-diaminopropranolol (pnOH) isomers were synthesized and their activities against leukemia L1210 were tested. The conformations of their chelate rings were determined to be λ- and δ-gauche forms for R- and S-pnOH, respectively, by ¹³C-nuclear magnetic resonance and circular dichroism spectral analyses. Among the pnOH isomers, Pt(II) complexes containing R-pnOH showed higher antitumor activity than those containing S- or racemic pnOH. It seems that there may be a relationship between the conformations of the chelate rings and antitumor activity in the case of five-membered chelate rings.

Full text of DOI:10.1248/cpb.31.1469

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