Chemical and Pharmaceutical Bulletin p. 1469 - 1473 (1983)
Update date:2022-08-02
Topics:
Noji
Motoama
Tashiro
Kidani
Halogeno, sulfato, and nitrato Pt(II) complexes of 2,3-diaminopropranolol (pnOH) isomers were synthesized and their activities against leukemia L1210 were tested. The conformations of their chelate rings were determined to be λ- and δ-gauche forms for R- and S-pnOH, respectively, by 13C-nuclear magnetic resonance and circular dichroism spectral analyses. Among the pnOH isomers, Pt(II) complexes containing R-pnOH showed higher antitumor activity than those containing S- or racemic pnOH. It seems that there may be a relationship between the conformations of the chelate rings and antitumor activity in the case of five-membered chelate rings.
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Doi:10.1021/acs.jnatprod.6b00367
(2016)Doi:10.1248/cpb.31.1646
(1983)Doi:10.1055/s-2003-37122
(2003)Doi:10.1021/om050882g
(2006)Doi:10.1016/S0022-328X(00)89433-4
(1977)Doi:10.1039/P19830002011
(1983)
