A new class of nitrosoureas. VIII. Synthesis and antitumor activity of 3-substituted 1-(2-chloroethyl)-3-(trans-2-hydroxy-cyclohexyl)-1-nitrosoureas

DOI: 10.1248/cpb.31.1646

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1646 - 1651 (1983)

Update date:2022-08-02

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Authors:

Morikawa

Tsujihara

Takeda Takeda

Arai Arai

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Article abstract of DOI:10.1248/cpb.31.1646

A series of six 3-substituted 1-(2-chloroethyl)-3-(trans-2-hydroxycyclohexyl)-1-nitrosoureas (IVa-f) was prepared and tested for antitumor activities. Heating of cyclohexene oxide with various alkylamines followed by reaction with 2-chloroethyl isocyanate

Full text of DOI:10.1248/cpb.31.1646

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