Synthesis of some new substituted thiosemicarbazides as potential antiviral agents

Article abstract of DOI:10.1002/ardp.19833161002

Substituted thiosemicarbazides, synthesized by the condensation of substituted 5-chloro-diphenylamine-2-carboxylic acid hydrazides with appropriate arylisothiocyanates, have been tested for their antiviral activity against the plant virus, sunnhemp rosette virus, in vitro as well as in vivo and against the animal virus, ranikhet disease virus, in a stationary culture of chorioallantoic membranes of chick embryo. The majority of these compounds showed significant antiviral activity against both viruses. The structure-activity relationships have further been studied and are discussed.