Chemistry of Heterocyclic Compounds p. 863 - 867 (1983)
Update date:2022-08-02
Topics:
Zhestkov, V.P.
Voronin, V.G.
Portnov, Yu.N.
1-Aryl-3-(2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolyl)-5-oxopyrazoles were obtained by condensation of ethyl β-(2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolyl)-β-ketopropionate with arylhydrazines.Electron-donor substituents in the aromatic ring of the arylhydrazines accelerate the cyclization of the intermediate hydrazones, whereas electron-acceptor substituents hinder cyclization.
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Doi:10.1021/om050882g
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