propanolamines. 1. Novel β-Blockers with Ultrashort Duration of Action

Article abstract of DOI:10.1021/jm00374a013

Novel <(arylcarbonyl)oxy>propanolamines were synthesized and investigated as potential ultrashort-acting β-adrenergic receptor blockers.Many of these analogues exhibited good potency and short duration.The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.It has been selected as a candidate for further clinical study.Structure-activity relationships and structure-duration relationships for these new β-blockers are also discussed.