Journal of Medicinal Chemistry p. 1007 - 1016 (1984)
Update date:2022-07-30
Topics:
Kam, Sheung-Tsam
Matier, William L.
Mai, Khuong X.
Barcelon-Yang, Cynthia
Borgman, Robert J.
et al.
Novel <(arylcarbonyl)oxy>propanolamines were synthesized and investigated as potential ultrashort-acting β-adrenergic receptor blockers.Many of these analogues exhibited good potency and short duration.The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.It has been selected as a candidate for further clinical study.Structure-activity relationships and structure-duration relationships for these new β-blockers are also discussed.
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