SIMPLE AND CHEMOSELECTIVE SYNTHESIS OF KETONES FROM CARBOXYLIC ACIDS AND GRIGNARD REAGENTS USING DICHLOROTRIPHENYLPHOSPHORANE

DOI: 10.1246/cl.1983.1267

Source and publish data:

Chemistry Letters p. 1267 - 1270 (1983)

Update date:2022-08-03

Topics:

Authors:

Fujisawa, Tamotsu

Iida, Sachio

Uehara, Hiroshi

Sato, Toshio

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Article abstract of DOI:10.1246/cl.1983.1267

Dichlorotriphenylphosphorane was found to be a good condensation reagent for synthesis of ketones from carboxylic acids and Grignard reagents under mild conditions.Synthetic utility of the present method is demonstrated by the chemoselective reaction of carboxylic acids possessing such a functional group as halogen, cyano, or carbonyl.

Full text of DOI:10.1246/cl.1983.1267

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