Practical synthesis and evaluation of the biological activities of 1α,25-dihydroxyvitamin D3 antagonists, 1α,25- dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis

DOI: 10.1021/jm050738x

Source and publish data:

Journal of Medicinal Chemistry p. 2398 - 2406 (2006)

Update date:2022-08-03

Topics:

Authors:

Nakano, Yusuke

Kato, Yuko

Imai, Keisuke

Ochiai, Eiji

Namekawa, Jun-Ichi

Ishizuka, Seiichi

Takenouchi, Kazuya

Tanatani, Aya

Hashimoto, Yuichi

Nagasawa, Kazuo

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Article abstract of DOI:10.1021/jm050738x

A practical synthetic route to novel vitamin D antagonists of DLAM (1α,25-dihydroxyvitamin D₃-26,23-lactam) was developed from vitamin D₂ via the 1,3-dipolar cycloaddition reaction as a key step. Six DLAM derivatives (24 compounds) w

Full text of DOI:10.1021/jm050738x

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