Bioorganic and Medicinal Chemistry Letters p. 1240 - 1244 (2006)
Update date:2022-08-02
Topics:
Garcia Collazo, Ana-Maria
Koehler, Konrad F.
Garg, Neeraj
Faernegardh, Mathias
Husman, Bolette
Ye, Liu
Ljunggren, Jan
Mellstroem, Karin
Sandberg, Johnny
Grynfarb, Marlena
Ahola, Harri
Malm, Johan
Based on the examination of the crystal structure of rat TRβ complexed with 3,5,3′-triiodo-l-thyronine (2) a novel TRβ-selective indole derivative 6b was prepared and tested in vitro. This compound was found to be 14 times selective for TRβ over TRα in bi
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