Synthesis and biological activity of phospholipase C-resistant analogues of phosphatidylinositol 4,5-bisphosphate

DOI: 10.1021/ja060621d

Source and publish data:

Journal of the American Chemical Society p. 5642 - 5643 (2006)

Update date:2022-07-30

Topics:

Authors:

Zhang, Honglu

Xu, Yong

Zhang, Zheng

Liman, Emily R.

Prestwich, Glenn D.

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Article abstract of DOI:10.1021/ja060621d

The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P₂) is an important regulator in cell physiology. Hydrolysis of PtdIns(4,5)P₂ by phospholipase C (PLC) releases two second messengers, Ins(1,4,5)P_{3
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Full text of DOI:10.1021/ja060621d

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