
Organic Letters p. 2131 - 2134 (2006)
Update date:2022-07-31
Topics:
Paterson, Ian
Findlay, Alison D.
Florence, Gordon J.
A revised configurational assignment for the cytotoxic marine macrolide dolastatin 19 is proposed and validated by total synthesis. Key features of the route include an asymmetric vinylogous aldol reaction to install the isolated C13 stereocenter and (E)-
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