Carbohydrate Research p. 35 - 42 (1983)
Update date:2022-09-26
Topics:
Berti, Giancarlo
Caroti, Paola
Catelani, Giorgio
Monti, Luigi
L-Glutamic acid has been converted into a separable mixture of D-amicetono- and L-rhodinono-γ-lactones by a sequence involving transformation into (S)-γ-carboxy-γ-butyrolactone (2), conversion of 2 into the corresponding methyl ketone by the diazoketone route, and selective reduction with zinc borohydride or boranemethyl sulfide.Reduction of the two lactones with di-isobutylaluminium hydride gave the corresponding deoxy sugars.In spite of some improvements in the preparation of 2, the optical yield of this step was only ca. 80percent, but one crystallisation from chloroform raised the optical purity to 96percent.The subsequent steps produced a loss in optical purity of only 4percent.
View Morewebsite:http://www.tbbmed.com
Contact:86--21-50498136
Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Shijiazhuang City Xiehe Pharmaceutical Co., Ltd
Contact:+86-311-80817929
Address:Shangzhuang,Shijiazhuang,China
Zhejiang Kangfeng Chemical Co.,LTD.
Contact:+86-579-86709687
Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China
Contact:86-571-61063068
Address:LINAN
Doi:10.1021/ic3024265
(2013)Doi:10.1016/j.tetlet.2006.03.152
(2006)Doi:10.1055/s-0028-1088025
(2009)Doi:10.1016/S0022-328X(00)98703-5
(1984)Doi:10.1016/S0022-1139(00)85208-2
(1984)Doi:10.1021/ja0488986
(2004)
