Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas

DOI: 10.1016/j.bmcl.2008.09.020

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5481 - 5486 (2008)

Update date:2022-08-03

Topics:

Authors:

Jin, Jian

Wang, Yonghui

Shi, Dongchuan

Wang, Feng

Fu, Wei Fu, Wei

Davis, Roderick S.

Jin, Qi Jin, Qi

Foley, James J.

Sarau, Henry M.

Morrow, Dwight M.

Moore, Michael L.

Rivero, Ralph A.

Palovich, Michael

Salmon, Michael

Belmonte, Kristen E.

Busch-Petersen, Jakob

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Article abstract of DOI:10.1016/j.bmcl.2008.09.020

SAR exploration of multiple regions of a tyrosine urea template led to the identification of very potent muscarinic acetylcholine receptor antagonists such as 10b with good subtype selectivity for M₃ over M₁. The structure-activity r

Full text of DOI:10.1016/j.bmcl.2008.09.020

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